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Conferences - PhandTA 8

Scientific Program

ORAL CONTRIBUTIONS

IGC determinations of solubility parameter for characterization of pharmaceutical excipients
Katarzyna Adamska, Adam Voelkel
Poznań University of Technology, Institute of Chemical Technology and Engineering, Poland
Mercury Intrusion Porosimetry: Determination of Pore Size, Particle Size and Density of Dry and Wet Materials
J. Adolphs
Porotec GmbH, Hofheim, Germany
Correlation between Molecular Mobility and Isothermal Crystallization Kinetics for an Amorphous Pharmaceutical Drug Substance Investigated by Dielectric Techniques
J. Aliéa, J. Menegottob, S. Byardb, M. Bauerb, C. Lacabannea
a Polymer Physics Laboratory, Toulouse, France
b Sanofi-Synthelabo Research, France and UK
Biomacromolecules at work: watching the details by solution NMR methods
M. Allana, M. Barfieldb, F. Cordiera, J. Engela, D. Häussingera, P. Jensena,
J. Kahmanna, H.J. Sassa, C. Thompsona, S. Grzesieka
a Biozentrum, University of Basel, CH 4056 Basel, Switzerland
b Department of Chemistry, University of Arizona, Tucson, AZ 85721, USA
WETSYS: A New Tool to Explore the Effect of a Humid Atmosphere on a Sample
R. Andre, R. Naumann
Setaram Instrumentation, Caluire, France
Measurement of Solvation Energies, the Key to Understand Partitioning and Passive Transport of Drugs
A. Bauer-Brandla, G. Perlovicha,b
a Institute of Pharmacy, University of Tromsoe, Norway
b Institute of Solution Chemistry, Russian Academy of Sciences, Ivanovo, Russia
Chemometric analysis of calorimetric data - and the development of a photocalorimeter for use in photostability studies of pharmaceuticals
Anthony E. Beezer
School of Pharmacy, University of London, United Kingdom
Pharmaceutical evaluation of early development candidates: Miniaturized and automated early Polymorphism investigations
Harald Berchtold, Martin Bröckelmann, Winfried Heyse, Norbert Nagel, Laure Viola
Aventis, GPD Solid State Characterization, Frankfurt/Main, Germany
New Developments in Screening for Pharmaceutical Salts and Polymorphs: High Throughput versus Conventional Laboratory Scale Experimentation
Fritz Blatter, Rolf Hilfiker, Markus von Raumer
Solvias AG, Basel, Switzerland
Co-crystallization - The Supramolecular Synthesis
Roland Boesea, M. T. Kirchnera, A. Gehrkea, T. Bendeleb, R. Sustmannb
a Institut für Anorganische Chemie, Univ. Duisburg-Essen, Essen, Germany
b Institut für Organische Chemie, Univ. Duisburg-Essen, Essen, Germany
A new polymorph of glycine formed at high pressure
Elena V. Boldyrevaa,b, S.N. Ivashevskaya a,c, H. Ahsbahsd, H. Sowad, H.-P. Webere
a Novosibirsk State University, Russia
b the Russian Academy of Sciences, Novosibirsk, Russia
c Karelian Scientific Center Russian Academy of Sciences, Petrozavodsk, Russia
d Institute of Mineralogy, Philipps-Universitaet Marburg/Lahn, Germany
e Swiss-Norwegian Beamlines ESRF, Grenoble, France
Concentration of a supercritical gas absorbed in a polymer and the concomitant change in volume of the polymer
Séverine A. E. Boyera,b, Jean-Pierre E. Groliera
a Laboratory of Thermodyn. of Solutions + Polymers,  B. Pascal Univ., Aubière, France  
b Institut Francais du Pétrole, Lyon-Vernaison, France
A Novel Fluorescence Assay for DNA Synapsis and Ligation
David T. Cramba, Dennis Merklea,b, Susan P. Lees-Millerc
a Department of Chemistry, University of Calgary, Canada
b Department of Biochemistry and Molecular Biology, University of Calgary, Canada
Identification, Crystal Structure Solution and Refinement of Stable and Metastable Pharmaceutical Compounds by Powder Diffraction
W. I. F. Davida, K. Shanklanda, R. M. Ibbersona, C. R. Pulhamb
a ISIS Facility, Rutherford Appleton Laboratory, Chilton, United Kingdom
b School of Chemistry, The University of Edinburgh, United Kingdom
Mechanical Activation and Mechanical Alloying of Pharmaceutical Compounds
M. Descamps, J.F. Willart, S. Desprez, A. De Gusseme, V. Caron
LDSMM, UMR CNRS 8024, University Lille, Villeneuve d'Ascq, France
Crystal properties impacting on milling induced disorder
Robert T. Forbes
Drug Delivery Group, School of Pharmacy, University of Bradford, United Kingdom
The Lattice Energy of Organic Compounds: Thermodynamic Facts and Computer Simulation
Angelo Gavezzotti
Department of Structural Chemistry, University of Milano, Italy
Binding of Cu(II) and Cd(II) ions with DNA from Spirulina Platensis
Eteri Gelagutashvilia, David Djoxadzeb, Liguri Mosulishvilia
a E.L.Andronikashvili Institute of Physics, Georgian Acad. Sci., Tbilisi, Georgia
b Tbilisi State University, Georgia
Challenging analytical development for polyphasic new entities, case studies
D. Giron, S. Monnier, M. Mutz, F. Stowasser
Chemical and Analytical Development, Novartis Pharma AG, Basel, Switzerland
Benefits and Limitations of Crystal Structure Determinations for the Understanding of Host-Guest Supramolecular Complexation
A. Grandeurya, S. Petita, G. Gouhierb, S. Costea, G. Coquerela
a Sciences et Methodes Separatives, University of Rouen, France
b IRCOF, University of Rouen, France
Award for "Applied Physical Chemistry"
Influences of Mechanical Stresses on the Crystal and Molecular Structure of Piroxicam
David J.W. Granta, Agam R. Shetha, Francis X. Mullerb
a Department of Pharmaceutics, University of Minnesota, Minneapolis, USA,
b GlaxoSmithKline, USA
Characterization, Stability and Structure of Pharmaceutical Hydrates
David J.W. Grant
Department of Pharmaceutics, University of Minnesota, Minneapolis, USA
Crystal Forms of Thiamine Hydrochloride (Vitamin B1): New analytical Data of a compound with an intriguing solid state history
Ulrich Griesser
Department of Pharmaceutical Technology, University of Innsbruck, Austria
Ternary Solid-Liquid Equilibria for Crystallization of Pharmaceutical Components
Jean-Pierre E. Groliera, Mohammad H. Hamedib
a Laboratory of Thermodyn. of Solutions + Polymers,  B. Pascal Univ., Aubière, France  
b Mechanical Engineering Department, K.N. Toosi University, Tehran, Iran
Phase transition of hydrogen-bonded supramolecular assembly consisting of amphoteric molecules studied by DSC-XRD and DSC-FTIR
Daisuke Ishiib, Takeshi Yamadaa, Hirohisa Yoshidaa,c, Masaru Nakagawab,
Tomokazu Iyodab,c
a Dep. of Applied Chemistry, Graduate School of Engineer., Tokyo Metropolitan Univ., Japan
b Chemical Research Laboratory, Tokyo Inst. of Technol., Nagatsuda, Yokohama, Japan
c CREST, Japan Science and Technology Corporation, Japan
On-line monitoring of Solvent Mediated Polymorphic Conversion by Isothermal Microcalorimetry
Peter Johansson
Thermometric AB, Järfälla, Sweden
Thermal Safety Calorimetry - Comparison of Measurements
J. Hakla, Ralf Meierb
a CALS AG, CH-4123 Allschwil, Switzerland
b Systag Systemtechnik Deutschland GmbH, Rosbach, Germany
Polymorphism and structural phase transitions in sodium disilicate (Na2Si2O5)
Volker Kahlenberg
Inst. of Mineralogy and Petrography, University of Innsbruck, Austria
DSC Signal Optimization with BeFLAT® and ISSP® in Pharmaceutical Applications
Erwin Kaisersberger, Markus Hollering, Elena Moukhina
Netzsch Gerätebau GmbH, Selb, Germany
Thermodynamic and kinetic studies on R(+) and S(-)-2,2'-dihydroxy-1-,1'-binaphthyls in solid state
Takayoshi Kimura, Yumi Toshima, Kousuke Morishima, Masashi Matsumato,
Manami Miyamoto, Tadashi Kamiyama
Dep. of Chemistry, Faculty of Sci. + Technol., Kinki University, Higashi-osaka Japan
Electron Crystallography – a tool to solve polymorphic structures ?
Ute Kolb
Institute of Physical Chemistry, Johannes Gutenberg University, Mainz, Germany
Review, New Insights and Selected Examples of Desolvation Investigations
Franck Mallet, Samuel Petit, Gérard Coquerel
Sciences et Methodes Separatives, University of Rouen, France
Resolution of Differential Scanning Calorimeters
Erwin Martia, Erwin Kaisersbergerb, Wolf-Dieter Emmerichb
a APCh Marti Consulting, Basel, Switzerland
b Netzsch Gerätebau GmbH, Selb, Germany
Interactions of detergents with lipid bilayers and monolayers studied by Isothermal Titration Calorimetry and Infrared Reflection Absorption Spectroscopy
Annette Meister, Andreas Kerth, Katja Beyer, Alfred Blume
Martin Luther University Halle-Wittenberg, Institute of Physical Chemistry, Germany
Did you got all Information from your Sample ?
Gisbert Naundorfa, Tim Mannb, Paul Gabbottb
a PerkinElmer (Schweiz) AG,  Schwerzenbach, Switzerland
b PETA Solutions, Beaconsfield, United Kingdom
Solid State Pharmaceuticals: Thermal and Photo- Stability
Csaba Novaka, Michael E. Brownb, Beverley D. Glassc
a Budapest Univ. of Technol. +Econ., Research Group of Techn.  Analyt. Chem. ,Hungary
b Chemistry Department, Rhodes University, Grahamstown, South Africa
c School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Australia
Application of Raman and IR Spectroscopy in Pharmaceutical Development
Sabine Pfeffer-Hennig, Miriam Bellus
Chemical and Analytical Development, Novartis Pharma AG, Basel, Switzerland
Chiral selectivity of the crystal packing in binary systems of enantiomers. A new way to quantify chirality
Ludovic Renou, Servane Coste, Gérard Coquerel
UC2M2, University of Rouen, France
Investigation of weak transitions in pharmaceutically relevant compounds
Rudolf Riesen, Matthias Wagner
Mettler-Toledo GmbH, Schwerzenbach, Switzerland
Non-destructive Analysis by Raman Spectroscopy
Bernhard Schrader
Physical and Theoretical Chemistry, University of Essen, Germany
The effect of halogenation on membrane binding and permeation
Anna Seelig
Department of Biophysical Chemitsry, Biocenter, University of Basel, Switzerland
Cell penetrating peptides – How can they get through membranes ?
J. Seeliga, A. Zieglerb, X. Li Blattera, P. Nervia ,A. Seeliga
a Biozentrum, University of Basel, Basel, Switzerland
b Boston University, Proteoglycan and Glycosaminoglycan Structure Laboratory, USA
Phospholipid membrane properties determining drug permeation
Marc Sutter, Tamara Fiechter, Georg Imanidis
Institute of Pharmaceutical Technology, University of Basel, Switzerland
Investigating the Kinetics of Moisture-Induced Crystallization of Amorphous Lactose
Frank Thielmanna, Daniel Burnettb
a Surface Measurement Systems, London, United Kingdom
b Surface Measurement Systems, Allentown, USA
Terahertz Spectroscopy
Terry Threlfall, Phil Taday
University of Southampton, Teraview Ltd, Cambridge, UK
Rational screening in solid form selection
Arjen van Langevelde, Erwin Blomsma, Stéphanie Mulder
Avantium Technologies BV, Amsterdam, The Netherlands
Heat Capacities of Liquids: The Quest for a Molecular-Based Description
Emmerich Wilhelm
Department of Physical Chemistry, University of Wien, Austria
Surface Properties of Milled and Unmilled Form I Paracetamol Powders
Daryl R. Williams, Jerry Y. Y. Heng
Dep. of Chemic. Engineering + Chemical Technology, Imperial College, London, UK
Drug Substance in Drug Product: Solid State Identification and Particle Size Determination in Tablets
Gabriele Winter
Schering AG, Berlin, Germany
Chiral recognition - investigated by IG-calorimetry and microgravimetry
Gert Wolf, J. Seidel, R. Kirchner, D. Waehlisch
Institute of Physical Chemistry, Technical University of Freiberg, Germany

POSTERS

Application of Thermal Analysis and X-Ray Diffraction Methods in the Study of Resolutions via Derivatives
Laura Bereczkia, József Schindlerb, Petra Bombiczc, Katalin Marthid, György Pokola,
Elemér Fogassyb
a
Institute of General + Analyt. Chem., Budapest Univ. of Technol. + Econ., Hungary
b Dep. of Organic Chemical Technology, Budapest Univ. of Technol. + Econ., Hungary
c Institute of Structural Chemistry, Hungarian Academy of Sciences, Budapest, Hungary
d Res. Group of Techn. Analyt. Chem., Budapest Univ. of Technol. + Econ., Hungary
Monitoring the elimination of solvents from pharmaceutical powders by a SPME-direct method
J. Bessea, F. Bigoua, J. -L. Luisiera, R. Nzéboa, P. Pichlerb, R. Rosséa
a Haute Ecole Valaisanne, HEVs, SION, Switzerland
b Brechbühler AG, SCHLIEREN, Switzerland
Optimizing the stability of a commercial compound using a high-throughput approach for forced degradation and excipient compatibility studies
Eric Carlson, Isabel Galdo, Thomas Kudla
Symyx Technologies, Sunnyvale, CA, USA
Large Scale Fractionation of Polymers for Special Applications
John Eckelt, Bernhard Anton Wolf
Institute of Physical Chemistry, University of Mainz, Germany
Thermal and Structural Properties of Theophylline-7-acetic Acid
Ferdinando Giordanoa, Anastasia Foppolib, Andrea Gazzanigab, Mino R. Cairac,
Sibulelo Vilakazic
a Dipartimento Farmaceutico, Università di Parma, Italia
b Istituto Chimico Farmaceutico, Università di Milano, Italia
c Department of Chemistry, University of Cape Town, South Africa
Two Polymorphs - Which One is Stable at Ambient Conditions ?
Anette Frost Jensen, Finn Junager, Susanne B. Laustsen, Pernille Rasmussen,
Claus U. Jessen, Hanne T. Kornø, John Bondo Hansen
Novo Nordisk A/S, Research & Development, Maaloev, Denmark

Crystal Polymorphs of Metazachlor: Isolation, Morphology and Crystal Structure Analysis
Ram K. R. Jettia, M. Haddowb, P. Erkb, V. Kahlenbergc, K. Wurstd, D. Weiganda,  J. Griessera
a Institute of Pharmacy, University of Innsbruck, Austria
b Research Center, BASF AG, Ludwigshafen, Germany
c Department of Mineralogy, University of Innsbruck, Austria
d Institute of General, Inorg. + Theoret. Chem., University of Innsbruck, Austria

Thermoanalytical testing of microspheres containing Diltiazem hydrochloride and Tolperisone hydrochloride
T. Hekmatara, G. Regdon jr., P. Sipos, I. Erös, K. Pintye-Hódi
Department of Pharmaceutical Technology, University of Szeged, Hungary
The uptake of solvents into drugs and their influence on the stability of polymorphs
Sebastian Kaerger, Frank Stowasser, Stephanie Monnier, Michael Mutz, Danielle Giron
Novartis Pharma AG, Chemical and Analytical Development, CH-4002 Basel
Release of Timolol Maleate from pH-sensitive Poly (methacrylic acid-co-2-hydroxyethyl methacrylate) Hydrogels
I. Katimea, J.L. Escobarb, E. Hernaeza, L. Pereza, J. Veladac
a Departamento de Quimica Fisica, Universidad del Pais Vasco, Spain
b Instituto de Biomateriales, Universidad de la Habana, Cuba
c GlaxoSmithKline, Weybridge, Surrey, United Kingdom
Adsorption and accumulation of Cd(II) ions by Spirulina platensis cells
A. Khizanishvili, A. Belokobilsky, L. Mosulishvili, E. Ginturi, N. Kuchava, A. Rcheulishvili
E. Andronikashvili Institute of Physics Academy of Sciences Georgia, Tbilisi, Georgia
Solid-state characterization of mesalazine bromide monohydrate
Ana Kwokala, Michaela Horvata, Petar Tudja aDominik Cincicb, Ernest Meštrovica,
Biserka Cetina-Cižmeka
a PLIVA-Research and Development, Ltd., Zagreb
b Laboratory of General and Inorganic Chemistry, Faculty of Science, Zagreb
Analytical Investigation of the Excipient Polysorbate 80
Francine I. Lorenz, Hans R. Altorfer
Institute of Pharmaceutical Sciences, ETH Zuerich, Switzerland
Problems encountered in case of compounds having a low enantiotropic transition
S. Monnier, T. Buser, P. Piechon, M. Bellus, D. Giron
Chemical & Analytical Development, Novartis Pharma AG, Basel, Switzerland
Application of Combined Thermoanalytical Techniques on the Investigation of Organic Compounds
Cs. Novaka, Zs. Ehena, T. F. Mourab, L. P. Fernandesb
a Institute of General and Analytical Chemsitry, University of Budapest, Hungary
b Departamento di Farmacia, Universidade Federal do Rio Grande do Norto, Natal, Brazil

Calorimetric observation of lactose crystallisation in skim milk and whey protein concentrate powders
A. Raemy, F. Morgan, R. Baechler, C. Appolonia Nouzilee, G. Vuataz
Nestec Ltd., Lausanne, Switzerland

Equipment Qualification for FT-IR / FT-NIR
Albrecht Rager
Bruker Optik GmbH, Ettlingen, Germany

Isostructural Polymorphs of the Local Anaesthetic Drugs Falicaine and Dyclonine
Andrea C. Schmidta, Robin K. Harrisb, Ulrich J. Griessera,
a Department of Pharmaceutical Technology, Univ. of Innsbruck, Innsbruck, Austria
b Department of Chemistry, University of Durham, United Kingdom

Two - Photon Excitation Fluorescence Cross - Correlation Spectroscopy for Ligand Binding Assays
Jody L. Swifta, David T. Cramba, Tanya E.S. Dahmsb
a Department of Chemistry, University of Calgary; Canada
b Department of Chemistry, University of Regina; Canada
Chiral and Racemic Structures of Tartrate Salts
Terry Threlfall, Thomas Gelbrich, Mike Hursthouse, Susanne Hutt, Eva Seeger
University of Southampton, United Kingdom, University of Leipzig, Germany
A Calorimetric Study of Erythritol
Luciana I. N. Tomé, A. J. Lopes Jesus, M. Margarida F. P. M. Antunes,
Teresa M. R. Maria, M. Luísa P. Leitão, M. Ermelinda S. Eusébio, J. S. Redinha
Departamento de Química, Universidade de Coimbra, Portugal
Applications of Raman Microscopy: Fast Scanning Chemical Mapping of Drug Delivery Systems
S. D. Warda, S. Y. Luka, C. E. Maddena, D. Le Rouxa, N. Patela, A. P. Parkera,
C. J. Robertsb
a Molecular Profiles Ltd., Nottingham, United Kingdom
bLaboratory of Biophysics + Surface Analysis, Univ. of Nottingham, United Kingdom
A Silicon chip based flow-through calorimeter for bio-chemical and screening applications
J. Lerchnera, G. Wolfa, M. Nietzschb, M. Krügelb
a TU Bergakademie Freiberg, Germany
b ”Eurotronics” Ges. wiss. Gerätebau mbH, Leipzig, Germany
MTDSC analysis of amorphous Nifedipine using sinusoidal and linear modulation of temperature program
Natalija Zajca, Geza Regdon jr.b, Klara Pintye-Hodib, Stane Srcica
a University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia
b University of Szeged, Department of Pharmaceutical Technology, Szeged, Hungary

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