Scientific Program
of PhandTA 5

euro_logo2.jpg (8359 Byte)


Tuesday, 19. September, 2000 Wednesday, 20. September, 2000 Thursday, 21. September, 2000 Poster



Tuesday, 19. September, 2000

08:00 – 09:20

Registration, Coffee


Opening of PhandTA 5

J. Brokatzky-Geiger, Novartis Pharma AG, Basel
E. Marti, President of eurostar-science and STK, Basel


Chairman: E. Marti

09:40 – 10:10 KC 1

Virtual Experiments – A Modern Alchemy?

A. Vedani
Biographics Laboratory 3R, Basel, CH

10:10 – 10:30 SC 1

The Application of Experimental and Computational Tools to Solve Complex Polymorphism Problems of Pharmaceutical Substances

Mrs. S. Pfeffer, P. Piechon, C. Goldbronn, L. Viola, D. Giron
Novartis Pharma AG, Basel, CH

10:30 – 10:50 SC 2

Physicochemical Properties of Emetine Dihydrochloride

U. Griesser, A. Burger
Institute for Pharmacognosy, University of Innsbruck, A

10:50 – 11:30

Poster Session, Coffee


Chairman: A Hörmann

11:30 – 12:00 KC 2

Physical Chemistry at Solvias: Research, Development, and Services

R. Hilfiker
Solvias AG, Basel, CH

12:00 – 12:20 SC 3

TGA-FTIR: The Use of Reduced Pressure

A. Rager 1, R.S. Jackson 2
Bruker Optik GmbH, Ettlingen, D
2 Bruker Optics, Billerica, USA

12:20 – 12:40 SC 4

Thermal Analysis and its Benefits in the Pharmaceutical and Related Industry

S. Goth 1, W. Surer 2

1 Perkin Elmer AG, Huenenberg, CH

2 Lab Plus AG, CH

12:40 – 14:00



Chairman: H.R. Oswald

14:00 – 14:50 PL 1

Force Measurements between Single Molecules: Relation to Thermodynamic Data

T. Strunz, M. Hegner, K. Oroszlan, I. Schumakovitch,H.-J. Güntherodt
Institute of Physica, University of Basel, Basel, CH

14:50 – 15:40 PL 2

Pulse Thermal Analysis: Applications in Gas - Solid Reactions

M. Maciejewski
Swiss Federal Institute of Technology, Zürich, CH

15:40 – 16:40

Opening of the Instrument Exhibition, Poster Session, Coffee


Chairman: R. Hilfiker

16:40 – 17:00 SC 5

Liquid-Phase Caloric Properties from VLE Data: Dilute Solutions

E. Wilhelm
University of Wien, A

17:00 – 17:30 KC 3

Consequences of Solvation Phenomena on Thermal Measurements and Chemical Safety

S. Walter, C. Cogneville, A. Hadj-Mebarek
Ecole Nationale Supérieure de Chimie de Mulhouse, Mulhouse, F

17:30 – 17:50


17:50 – 18:20 KC 4

State of the Art Instrumentation and Trends in Development of Hard- and Software for Thermal Analysis

W.-D. Emmerich, E. Kaisersberger, J. Opfermann
Netzsch-Gerätebau GmbH, Selb, D

18:20 – 19:00 WO 1

Instrumentation and Methods

E. Marti, E. Kaisersberger, W. Kunze


Reception Wildt'sches Haus, Petersplatz 13, Basel
Aperitif sponsered by Mettler-Toledo AG, Greifensee

The "Wildt'sches Haus" is one of the out-standing historical buildings of Basel. Because of the wooden floor, no highheels are allowed.

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Wednesday, 20. September, 2000


Chairman: S. Walter

08:30 – 08:50 SC 6

Reaction Calorimetry in New Dimensions

P.E. Meier
SYSTAG Systemtechnik AG, Rüschlikon, CH

08:50 – 09:10 SC 7

Introduction of a New Reaction Calorimeter Called DRC

Ch. Mathonat, L. Benoist
Setaram, Caluire, F

09:10 – 09:40 KC 5

Physicochemical Methods for Stability Research and Formulation Development

F. Blatter
Solvias AG, Basel, CH

09:40 – 10:30

Poster Session, Exhibition of Instruments, Coffee


Chairman: S. Petit

10:30 – 10:50 SC 8

Solid State Characterizations of Pharmaceutical Hydrates

Mrs. D. Giron, C. Goldbronn, S. Pfeffer, M. Mutz, P. Piechon
Novartis Pharma AG, Basel, CH

10:50 – 11:10 SC 9

X-Ray Diffraction as Function of Relative Humidity

A. Burkhard, A. Geoffroy
Solvias AG, Basel, CH

11:10 – 11:40 KC 6

The Effect of Relative Humidity on the Glass Transition Temperature of Sugars Determined by IGC

D.A. Butler, F. Thielmann, D.R. Williams
Surface Measurement Systems Ltd., London, UK

11:40 – 12:00 SC 10

Determination of Glass Transition Temperature and Specific Heat of Moist Samples Using TMDSC

R. Riesen, M. Schubnell, J.E.K. Schawe
Mettler-Toledo GmbH, Schwerzenbach, CH

12:00 – 13:30


Chairman: E. Marti

Award for "Applied Physical Chemistry"

13:30 – 14:30 AL 1

Peptide-Membrane Interactions. Electrostatics and Cooperativity

J. Seelig
Biocenter of the University of Basel, Basel, CH

14:30 – 14:50 Break
Chairwoman: Mrs. S. Pfeffer
14:50 – 15:20 KC 7

Are Crystal Structures Predictable? A Progress Report

J. Dunitz
Swiss Federal Institute of Technology, ETH Zürich, CH

15:20 – 15:50 KC 8

"Isoenergetic" Polymorphs of Cimetidine

A. Bauer-Brandl 1, E. Marti 2, E. Wappler3, M. Suurkuusk 4, H. Birkedal 5, P. Pattison 5
Universitetet i Tromsø, Institut for Farmasi, Breivika, Tromsø, N
2 Solvias AG, Basel, CH
3 WSK Messtechnik GmbH, Limesheim, D
4 Thermometric AB, Järfalla, S
5 University of Lausanne, Institute of Crystallography, Lausanne, CH

15:50 – 16:10 SC 11

A Comperative Study of the Effect of Pressure on the Polymorphism of Paracetamol and on Phenacetine

Mrs. E.V. Boldyreva 1, T.P. Shakhtshneider 1, V.V. Boldyrev 1, H. Ahsbahs 2, H. Uchtmann 2
Russian Academy of Sciences and Novosibirsk State University, R
2 Centre of Material Science, Marburg, D

16:10 – 17:00 Poster Session, Exhibition of Instruments, Coffee
Chairman: J. Seelig
17:00 – 17:50 PL 3

Recognition of Polymorphic Antigens by the Immune System: Implications for Malaria Vaccine Design

G. Pluschke
Swiss Tropical Institute, Basel, CH

Meeting time for the Visit to the Zoo of Basel
Start of the guided tours by the experts: Dres. Th. Jermann, A. Heldstab, and J. Hess
19:45 Aperitif at the Zoo Restaurant
sponsored by Netzsch GerätebauGmbH, Selb, D and Solvias AG, Basel, CH
20:30 Conference Dinner

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Thursday, 21. September, 2000


08:30 – 10:00


General Assembly of the European Society for Applied Physical Chemistry at the Pharmacenter


Chairwoman: Mrs. A. Bauer-Brandl

08:30 – 08:50 SC 12



Thermal Analysis in the Design of Chiral Resolutions. Studies on o,o'-Dibenzoyl-
[2R,3R]-Tartaric Acid + Alcohol Supramolecular Systems

C. Kassai 1, R. Illés 2, G. Pokol 2, D. Kozma 1 , E. Fogassy 1
Department of Organic Chemical Technology, and
2 Institute of General and Analytical Chemistry, 
Budapest University of Technology and Economics, H

08:50 – 09:10 SC 13

Extended Thermal Analysis by Advanced Software Programs: Multicomponent Analysis, Purity, and Kinetics

J. Opfermann, E. Kaisersberger
Netzsch Gerätebau GmbH, Selb, D

09:10 – 09:30 SC 14

Excipient Compatibility Assessment by Isothermal Microcalorimetry

R.A. Winnike 1, M.A. Phipps 2, S.T. Long 1, F.A. Viscomi 1
Glaxo Wellcome Inc., Research Triangle Park, U.S.A.
2 Thermometric Ltd., Northwich, UK

09:30 – 10:30

Poster Session, Exhibition of Instruments, Coffee


Chairwoman: Mrs. D. Giron

10:30 – 10:50 SC 15

Polymorphism in the Binary System of Enantiomeric Dihydropyridines

Mrs. J.M. Rollinger, A. Burger
Institute for Pharmacognosy, University of Innsbruck, A

10:50 – 11:10 SC 16

Thermal Studies on Mebendazole

Mrs. B. Glass, M. Brown, E. Mopp, M. Aerebo
Rhodes University, Grahamstown, South Africa

11:10 – 11:30 SC 17

Solid Dispersions of Nimodipine and Polyoxyethylene - an Additive Prevents the Drug from Recrystallization

Mrs. N.A. Urbanetz, B.C. Lippold
Institute of Pharmaceutical Technology, Heinrich-Heine-University, Düsseldorf, D

11:30 – 11:40



Chairman: U. Griesser

11:40 – 12:00 SC 18

Quantitative Analysis of Crystallinity of Pharmaceuticals Powders: Industrial Needs

M. Mutz, F. Zaman, D. Giron
Novartis Pharma AG, Basel, CH

12:00 – 12:30 KC 9

Dehydration and Crystallization Behaviour of a-Lactose Mono-hydrate: New Unexpected Results

St. Garnier, S. Petit, G. Coquerel
Université of Rouen, Rouen, F

12:30 – 14:00



Chairman: E. Marti

Award for "Applied Chemical Thermodynamics" of the STK

14:00 – 14:50 AL 2

Polyacrylates and Chitosanderivatives are Safe Polymeric Penetration Enhancers for Hydrophilic Drugs

H.E. Junginger, M. Thanou, J.C. Verhoef
Leiden/Amsterdam Center for Drug Research, University of Leiden,NL

14:50 – 15:00



Award Young Scientist for "Applied Physical Chemistry"

15:00 – 15:40 AL 3

Binding of the Marine Sponge Pigment Fascaplysin to DNA: Comparison of Calorimetric and Spectroscopic Titrations

A. Hörmann 1, B. Chaudhuri 2, H. Fretz 2
Solvias AG, Basel, CH
2 Oncology Research Novartis Pharma AG, Basel, CH

15:40 – 16:20



Chairman: H.E. Junginger

16:20 – 16:50 KC 10

Modification of Polymers by Supercritical Gases

J.-P.E. Grolier
University Blaise Pascal, Aubiere, F

16:50 – 17:40 PL 4

Liposomal Drug Targeting Systems: From Concept to Reality

G. Storm, D.J.A. Crommelin
Institute of Pharmaceutical Sciences, Utrecht University, NL

17:40 – 18:10 KC 11

Thermal Transitions of Nonionic Detergent Micelles

E. Grell 1, H. Ruf 1, M. Mutz 2, M. von Raumer 3, A. Hörmann 3, R. Schneider 4,
G. Ilgenfritz 4, I. Grillo 5, M. Kriechbaum 6, P. Laggner 6

1 Max-Planck-Institut für Biophysik, Frankfurt a. M., D
2 Novartis Pharma AG, Basel, CH
3 Solvias AG, Basel, CH
4 Institut für Physikalische Chemie der Universität Köln, D
5 Institut Max von Laue - Paul Langevin, Grenoble, F
6 Institut für Biophysik und Röntgenstrukturforschung, Österreichische Akademie der
  Wissenschaften, Graz, A

18:10 – 18:20



Chairman: U. Ch. Hofmeier

18:20 – 18:40 SC 19

Discrimination of Release Kinetics of Loaded Microbeads Designed for Embolisation: A New Methodology

F. Amyot 1, K. Jurski 1, V. Boudy 2, J.L. Counord 1, G. Guiffant 1, J. Dufaux 1
J.C. Chaumeil 2
Laboratoire de Biorhéologie et d’hydrodynamique Physicochimique, C.N.R.S. 7057, Paris, F
2 Service Recherche et Développement Galénique, Pharmacie Centrale des Hôpitaux de Paris


18:40 – 19:10 KC 12

Thermal Analysis for the Characterization of Drug Substances and Excipients

E. Kaisersberger 1, E. Marti 2
Netzsch-Gerätebau GmbH, Selb, D
2 Solvias AG, Basel, CH


Closing of the PhandTA 5


Informal Dinner

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PO A 1

Microcrystallisation – A Study of the Influence of the Substrate on Crystallisation and on the Formation of Polymorphic Forms

O.M.R. Wenger 1, A.G. Helg 2, C. Marcolli 2, M. Szelagiewizc 2
1 Pharmacenter of the University of Basel, Basel, CH
2 Solvias AG, Basel, CH


PO A 2

Polymorphism of Oxybuprocaine-HCl

A. Schmidt, U. Griesser, A. Burger
University of Innsbruck, A


PO A 3

Thermal, Spectroscopic, X-ray Diffraction, and Microscopic Investigations of Glassy State of Doxazosin Mesylate

M. Grcman 1, F. Vrecer 2, T. Meden 1
1 Krka d.d., Research and Development Division, Novo Mesto, Slo
2 Faculty of Chemistry and Chemical Technology, University of Ljubljana, Slo


PO A 4

Application of DSC Method to Analyse Some Drugs g, b -Sterilized

B. Marciniec 1, L. Wachowski 2
1 Department of Pharmaceutical Chemistry, Karol Marcinkowski University Medical Sciences, Poznan, Poland
2 Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland


PO A 5

Detection of Low Crystalline Amounts of a Drug Substance in Solid Dispersions by DSC

K. Fiebich
Novartis Pharma AG, Basel, CH


PO A 6

Synthesis and Applications of Some Polymeric Conjugates of Thymol or Eugenol

A.G. Anghelescu-Dogaru 1, G.C. Chitanu 1, G.G. Bumbu 1, A. Poiata 2, C. Vasile 1, A. Carpov 1
1 Petru Poni Institute of Macromolecular Chemistry, Romanian Academy, Iasi, Ro
2 Faculty of Pharmacy, Gr.T. Popa University of Medicine and Pharmacy , Iasi, Ro


PO A 7

Thermal Characterization of some New bis-Xanthine Derivatives

G.G. Bumbu 1, L. Profire 2, Gh. Danila 2, C. Vasile 1
1 Petru Poni Institute of Macromolecular Chemistry, Romanian Academy, Iasi, Ro
2 Faculty of Pharmacy, Gr.T. Popa University of Medicine and Pharmacy , Iasi, Ro


PO A 8

Thermomicroscopy and Differential Thermal Analysis of Terfenadine

J. Canotilho 1, S.R. Ferreira 2, F.S. Costa 1, A.T. Sousa 1, J.S. Redinha 2, M.L.P. Leitão 2
1 Facultade de Farmacia, Universidade de Coimbra, P
2 Faculdade de Ciências e Tecnologia, Universidade de Coimbra, P


PO A 9

Thermal Investigation of Propyphenazone-Caffeine Mixture

B. Cetina-Cizmek 1, V. Grdinic 1, M. Tudja 2, P. Tudja 2, M. Horvat 2
1 Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia
2 PLIVA d.d., Zagreb, Croatia


PO A 10

The Characterisation of Pharmaceutical Powders by Solution Calorimetry

F. Zaman, M. Mutz, P. Schwab, P. Piechon, D. Goldbronn, D. Giron
Novartis Pharma AG, Basel, CH


PO A 11

Crystallization Development assisted by Lasentec FBRM

P. Schirig
PS Prozesstechnik GmbH, Basel, CH


PO A 12

On the Polymorphism of Plant Protection Substances: Physicochemical Properties of Metazachlor Crystal Forms

D.K. Weigand, J.M. Rollinger, A. Burger
University of Innsbruck, A


PO A 13

Studies on the Melting Process of Acetylsalicylic Acid Single Crystals

G.L. Perlovich1,2, A. Bauer-Brandl1
1 Institutt for Farmasi, Universitetet i Tromso, Tromso, N
2 Institute of Solution ChemistryRussian Academy of Sciences, Ivanovo, RUS


PO B 1

Control of Size and Morphology of a-Lactose Monohydrate Crystals by Using Structurally Related Additives. Possible Consequences by Dehydration Behaviour and Amorphization

St. Garnier, S. Petit, G. Coquerel
University of Rouen, Rouen, F


PO B 2

A Calorimetric Study of Phospholipid Hydration

N. Markova1, E. Sparr1, L. Wadsö 2, H. Wennerström1
1 Physical Chemistry, University of Lund, S
2 Division of Building Materials, University of Lund, S


PO B 3

The Study of Vitamin C by Thermal Analysis and FTIR-Spectroscopy

V. Wegmann, M. Egelkraut-Holtus, K. Pommerenke
Shimadzu Deutschland GmbH, Duisburg, D


PO B 4

Study of Thermal Analysis of Di-Methacrylate of Tri-Ethylene Glycol

J. Notay 1, S.M. Dahiwale 1, S.D. Pradhan 2, S.S. Bhagade 3
1 Naval College of Engineering, INS Shivaji Lonavla, India
2 National Chemical Laboratory Pune, India
3 Laxminarayan Institute of Technology, Nagpur University, Nagpur, India


PO B 5

Information about Morphology and Thermal Properties of Semisolid Phospholipid Preparations obtained by Electron Microscopy, DSC and Rheometry

J. Bender and R, Schubert
Department of Pharmaceutical Technology, University of Freiburg, D


PO C 1

The Effect of Punch Velocity on the Initial Compression Stage of Caffeine and Microcristalline Cellulose: Modelling by a Modified Heckel Equation

C. Bürger, H. Leuenberger
Pharmacenter, University of Basel, Basel, CH


PO C 2

Glassy Solid Solutions of Poorly Soluble Drugs in Isomalt for a Rapid Bioavailability

M. Langer, N.A. Urbanetz, B.C. Lippold
Institute of Pharmaceutical Technology, University of Düsseldorf, Düsseldorf, D


PO C 3

Stability Investigation of Drug-Cyclodextrin Inclusion Complexes

M. Zelenak 1, Z. Neizer 1, Cs. Novak 1, J. Sztatisz 1, S. Gal 1, G. Liptay 1, V.J. Fernandes Jr. 2, E. Carvalho 2
1 Institute of General & Analytical Chemistry, University of Technics and Economics, Budapest, H
2 Universidade Federal do Rio Grande do Norte, Natal, Brasil


PO C 4

Characterization of Thermal Stability by ADSC and TG-FTIR on Drugs

F. Hoffmann
Mettler-Toledo GmbH, Giessen, D


PO C 5

Studies on Biodegradable Silica fibers containing Dexmedetomidine

T. Czuryszkiewicz1, J. Ahvenlammi2, M. Lindén1
1 Department of Physical Chemistry, Abo Akademi University, Turku, FIN
2 Institute of Fiber, Textile and Clothing Science, University of Technology, Tampere, FIN


PO D 1

Molecular Ionics of Anion Receptor Molecules: A Microcalorimetric Study

D. Grell 1, E. Grell 2, P. Bugnon 3, B. Dietrich 1, G. Quinkert 4, J.-M. Lehn 1
1 Institute Le Bel, Université Louis Pasteur, Strasbourg, F
2 Max-Planck-Institut für Biophysik, Frankfurt a. M., D
3 Institute de Chimie Analytique, Université de Lausanne, CH
4 Institute for Organic Chemistry, J.W. von Goethe University, Frankfurt a. M., D


PO D 2

Effect of Chlorinated Phenols on the Structure of Model Membranes

Á. Csizar 1, A. Bóta 1, Cs. Novak 2, G. Liptay 2, E. Klumpp 3, G. Subklew 3
1 Institute of Phys. Chemistry, University of Technics and Economics, Budapest, H
2 Department of General & Analytical Chemistry, Univ. Techn. Econ., Budapest, H
3 Institute of Applied Physical Chemistry, Research Centre Jülich, D


PO E 1

Temperature Dependence of the Raman Spectra of Amorphous Glucose

S. Söderholm, N. Meiander, Y.H. Roos
University of Helsinki, FIN


PO E 2

Applications of TGA-MS-Coupling

R. Schiller
Schering AG, Berlin, D


PO E 3

Progress in the Standardisation of Particle and Surface Characterisation

E. Robens 1, K.-F. Krebs 2, K. Meyer 3, K.K.Unger 1, A.Dabrowski 4
1 Institute of Anorg. and Analytical Chemistry, J. Gutenberg University, Mainz, D
2 Merck KGaA, LAB CHROM Synthese, Darmstadt, D
3 Bundesanstalt für Materialforschung und -prüfung, Berlin, D
4 Faculty of Chemistry, Maria Curie-Sklodowska University, Lublin, Poland


PO E 4

Application of Jäntti's Method for General Use

J.A. Poulis 1, C.H. Massen 1, E. Robens 2, P. Staszczuk 3
1 Faculty of Technical Physics, Technical University Eindhoven, NL
2 Institute of Anorg. and Analytical Chemistry, J. Gutenberg University, Mainz, D
3 Faculty of Chemistry, Maria Curie-Sklodowska University, Lublin, Poland


PO E 5

Coupled DSC-Microscope System and its Application to Pharmaceuticals

K. Pommerenke, M. Ohta
Shimadzu Deutschland GmbH, Duisburg, D


PO E 6

40 Jahre Shimadzu Thermoanalyse

K. Holtzhauer
Shimadzu Schweiz GmbH, Reinach, CH



PO E 7

Indirect Calorimetry of Human Body Surface and New Force in Human Space-Time

A. Shiraishi
Shiraishi Hospital, Kosei-cho, Okayama City, J


PO E 8

Thermodynamic Study of Electrolytes Solutions. Thermodynamic Properties of Ammonium Aqueous Electrolytes Solutions from Solubility Measurement

R. Sirbu
Faculty of Pharmacy, "Ovidius" University, Constanza, Ro


PO E 9

Thermodynamic Properties of NaSCN and KSCN in Binary and Ternary Aqueous Solutions at Liquid-Solid Equlibrium

R. Sirbu 1, M. Sirbu 2
1 Faculty of Pharmacy, "Ovidius" University, Constanza, Ro
2 Mircea cel Batrân, College of Constanza, Ro


PO E 10

The Ionic Activity Coefficients of Electrolytes in Aqueous Solutions Using Selective Electrodes and Cryoscopic Data

R. Sirbu 1, M. Sirbu 2
1 Faculty of Pharmacy, "Ovidius" University, Constanza, Ro
2 Mircea cel Batrân, College of Constanza, Ro


PO E 11

Scanning Microcalorimetry Investigation of Native and Iodized Spirulina Platensis Cell Culture

L. Topehishvili, G. Majagaladze, D. Tananashvili, J. Monaselidze
Institute of Physics, Georgian Academy of Sciences, Tbilisi, Georgia


PO E 12

DSC by TGA/SDTA 851e Considering Mass Changes

R. Riesen, K. Vogel
Mettler-Toledo GmbH, Schwerzenbach, CH


PO E 13

Expansion and Modulus Measurements during Shrinkage of Fibers; Simultaneous Load- and Temperature-Modulated TMA

R. Riesen, J.K.E. Schawe
Mettler-Toledo GmbH, Schwerzenbach, CH


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