Scientific Program


	Scientific Program of PhandTA 5

Tuesday, 19. September, 2000

Wednesday, 20. September, 2000

Thursday, 21. September, 2000

Poster

Tuesday, 19. September, 2000

08:00 – 09:20	Registration, Coffee
09:20	Opening of PhandTA 5 J. Brokatzky-Geiger, Novartis Pharma AG, Basel E. Marti, President of eurostar-science and STK, Basel
	Chairman: E. Marti
09:40 – 10:10 KC 1	Virtual Experiments – A Modern Alchemy? A. Vedani Biographics Laboratory 3R, Basel, CH
10:10 – 10:30 SC 1	The Application of Experimental and Computational Tools to Solve Complex Polymorphism Problems of Pharmaceutical Substances Mrs. S. Pfeffer, P. Piechon, C. Goldbronn, L. Viola, D. Giron Novartis Pharma AG, Basel, CH
10:30 – 10:50 SC 2	Physicochemical Properties of Emetine Dihydrochloride U. Griesser, A. Burger Institute for Pharmacognosy, University of Innsbruck, A
10:50 – 11:30	Poster Session, Coffee
	Chairman: A Hörmann
11:30 – 12:00 KC 2	Physical Chemistry at Solvias: Research, Development, and Services R. Hilfiker Solvias AG, Basel, CH
12:00 – 12:20 SC 3	TGA-FTIR: The Use of Reduced Pressure A. Rager ¹, R.S. Jackson ^{2 1} Bruker Optik GmbH, Ettlingen, D ² Bruker Optics, Billerica, USA

12:20 – 12:40 SC 4	Thermal Analysis and its Benefits in the Pharmaceutical and Related Industry S. Goth¹, W. Surer ² 1 Perkin Elmer AG, Huenenberg, CH ^{2 Lab Plus AG, CH}
12:40 – 14:00	Lunch
	Chairman: H.R. Oswald
14:00 – 14:50 PL 1	Force Measurements between Single Molecules: Relation to Thermodynamic Data T. Strunz, M. Hegner, K. Oroszlan, I. Schumakovitch,H.-J. Güntherodt Institute of Physica, University of Basel, Basel, CH
14:50 – 15:40 PL 2	Pulse Thermal Analysis: Applications in Gas - Solid Reactions M. Maciejewski Swiss Federal Institute of Technology, Zürich, CH
15:40 – 16:40	Opening of the Instrument Exhibition, Poster Session, Coffee
	Chairman: R. Hilfiker
16:40 – 17:00 SC 5	Liquid-Phase Caloric Properties from VLE Data: Dilute Solutions E. Wilhelm University of Wien, A
17:00 – 17:30 KC 3	Consequences of Solvation Phenomena on Thermal Measurements and Chemical Safety S. Walter, C. Cogneville, A. Hadj-Mebarek Ecole Nationale Supérieure de Chimie de Mulhouse, Mulhouse, F

17:30 – 17:50	Break
17:50 – 18:20 KC 4	State of the Art Instrumentation and Trends in Development of Hard- and Software for Thermal Analysis W.-D. Emmerich, E. Kaisersberger, J. Opfermann Netzsch-Gerätebau GmbH, Selb, D
18:20 – 19:00 WO 1	Instrumentation and Methods E. Marti, E. Kaisersberger, W. Kunze
20:00	Reception Wildt'sches Haus, Petersplatz 13, Basel Aperitif sponsered by Mettler-Toledo AG, Greifensee The "Wildt'sches Haus" is one of the out-standing historical buildings of Basel. Because of the wooden floor, no highheels are allowed.

Wednesday, 20. September, 2000

	Chairman: S. Walter
08:30 – 08:50 SC 6	Reaction Calorimetry in New Dimensions P.E. Meier SYSTAG Systemtechnik AG, Rüschlikon, CH
08:50 – 09:10 SC 7	Introduction of a New Reaction Calorimeter Called DRC Ch. Mathonat, L. Benoist Setaram, Caluire, F
09:10 – 09:40 KC 5	Physicochemical Methods for Stability Research and Formulation Development F. Blatter Solvias AG, Basel, CH
09:40 – 10:30	Poster Session, Exhibition of Instruments, Coffee
	Chairman: S. Petit
10:30 – 10:50 SC 8	Solid State Characterizations of Pharmaceutical Hydrates Mrs. D. Giron, C. Goldbronn, S. Pfeffer, M. Mutz, P. Piechon Novartis Pharma AG, Basel, CH
10:50 – 11:10 SC 9	X-Ray Diffraction as Function of Relative Humidity A. Burkhard, A. Geoffroy Solvias AG, Basel, CH
11:10 – 11:40 KC 6	The Effect of Relative Humidity on the Glass Transition Temperature of Sugars Determined by IGC D.A. Butler, F. Thielmann, D.R. Williams Surface Measurement Systems Ltd., London, UK
11:40 – 12:00 SC 10	Determination of Glass Transition Temperature and Specific Heat of Moist Samples Using TMDSC R. Riesen, M. Schubnell, J.E.K. Schawe Mettler-Toledo GmbH, Schwerzenbach, CH
12:00 – 13:30	Lunch
	Chairman: E. Marti Award for "Applied Physical Chemistry"
13:30 – 14:30 AL 1	Peptide-Membrane Interactions. Electrostatics and Cooperativity J. Seelig Biocenter of the University of Basel, Basel, CH
14:30 – 14:50	Break
	Chairwoman: Mrs. S. Pfeffer
14:50 – 15:20 KC 7	Are Crystal Structures Predictable? A Progress Report J. Dunitz Swiss Federal Institute of Technology, ETH Zürich, CH
15:20 – 15:50 KC 8	"Isoenergetic" Polymorphs of Cimetidine A. Bauer-Brandl ¹, E. Marti ², E. Wappler³, M. Suurkuusk ⁴, H. Birkedal ⁵, P. Pattison ^{5 1} Universitetet i Tromsø, Institut for Farmasi, Breivika, Tromsø, N ² Solvias AG, Basel, CH ³ WSK Messtechnik GmbH, Limesheim, D ⁴ Thermometric AB, Järfalla, S ⁵ University of Lausanne, Institute of Crystallography, Lausanne, CH
15:50 – 16:10 SC 11	A Comperative Study of the Effect of Pressure on the Polymorphism of Paracetamol and on Phenacetine Mrs. E.V. Boldyreva ¹, T.P. Shakhtshneider ¹, V.V. Boldyrev ¹, H. Ahsbahs ², H. Uchtmann ^{2 1}Russian Academy of Sciences and Novosibirsk State University, R ²Centre of Material Science, Marburg, D
16:10 – 17:00	Poster Session, Exhibition of Instruments, Coffee
	Chairman: J. Seelig
17:00 – 17:50 PL 3	Recognition of Polymorphic Antigens by the Immune System: Implications for Malaria Vaccine Design G. Pluschke Swiss Tropical Institute, Basel, CH
18:20 18:30	Meeting time for the Visit to the Zoo of Basel Start of the guided tours by the experts: Dres. Th. Jermann, A. Heldstab, and J. Hess
19:45	Aperitif at the Zoo Restaurant sponsored by Netzsch GerätebauGmbH, Selb, D and Solvias AG, Basel, CH
20:30	Conference Dinner

Thursday, 21. September, 2000

08:30 – 10:00	General Assembly of the European Society for Applied Physical Chemistry at the Pharmacenter
	Chairwoman: Mrs. A. Bauer-Brandl
08:30 – 08:50 SC 12	Thermal Analysis in the Design of Chiral Resolutions. Studies on o,o'-Dibenzoyl- [2R,3R]-Tartaric Acid + Alcohol Supramolecular Systems C. Kassai ¹, R. Illés ², G. Pokol ², D. Kozma ¹ , E. Fogassy ^{1 1} Department of Organic Chemical Technology, and ²Institute of General and Analytical Chemistry, Budapest University of Technology and Economics, H
08:50 – 09:10 SC 13	Extended Thermal Analysis by Advanced Software Programs: Multicomponent Analysis, Purity, and Kinetics J. Opfermann, E. Kaisersberger Netzsch Gerätebau GmbH, Selb, D
09:10 – 09:30 SC 14	Excipient Compatibility Assessment by Isothermal Microcalorimetry R.A. Winnike ¹, M.A. Phipps ², S.T. Long ¹, F.A. Viscomi ^{1 1}Glaxo Wellcome Inc., Research Triangle Park, U.S.A. ² Thermometric Ltd., Northwich, UK
09:30 – 10:30	Poster Session, Exhibition of Instruments, Coffee
	Chairwoman: Mrs. D. Giron
10:30 – 10:50 SC 15	Polymorphism in the Binary System of Enantiomeric Dihydropyridines Mrs. J.M. Rollinger, A. Burger Institute for Pharmacognosy, University of Innsbruck, A
10:50 – 11:10 SC 16	Thermal Studies on Mebendazole Mrs. B. Glass, M. Brown, E. Mopp, M. Aerebo Rhodes University, Grahamstown, South Africa
11:10 – 11:30 SC 17	Solid Dispersions of Nimodipine and Polyoxyethylene - an Additive Prevents the Drug from Recrystallization Mrs. N.A. Urbanetz, B.C. Lippold Institute of Pharmaceutical Technology, Heinrich-Heine-University, Düsseldorf, D
11:30 – 11:40	Break
	Chairman: U. Griesser
11:40 – 12:00 SC 18	Quantitative Analysis of Crystallinity of Pharmaceuticals Powders: Industrial Needs M. Mutz, F. Zaman, D. Giron Novartis Pharma AG, Basel, CH
12:00 – 12:30 KC 9	Dehydration and Crystallization Behaviour of a-Lactose Mono-hydrate: New Unexpected Results St. Garnier, S. Petit, G. Coquerel Université of Rouen, Rouen, F
12:30 – 14:00	Lunch
	Chairman: E. Marti Award for "Applied Chemical Thermodynamics" of the STK
14:00 – 14:50 AL 2	Polyacrylates and Chitosanderivatives are Safe Polymeric Penetration Enhancers for Hydrophilic Drugs H.E. Junginger, M. Thanou, J.C. Verhoef Leiden/Amsterdam Center for Drug Research, University of Leiden,NL
14:50 – 15:00	Break
	Award Young Scientist for "Applied Physical Chemistry"
15:00 – 15:40 AL 3	Binding of the Marine Sponge Pigment Fascaplysin to DNA: Comparison of Calorimetric and Spectroscopic Titrations A. Hörmann ¹, B. Chaudhuri ², H. Fretz ^{2 1} Solvias AG, Basel, CH ² Oncology Research Novartis Pharma AG, Basel, CH
15:40 – 16:20	Break
	Chairman: H.E. Junginger
16:20 – 16:50 KC 10	Modification of Polymers by Supercritical Gases J.-P.E. Grolier University Blaise Pascal, Aubiere, F
16:50 – 17:40 PL 4	Liposomal Drug Targeting Systems: From Concept to Reality G. Storm, D.J.A. Crommelin Institute of Pharmaceutical Sciences, Utrecht University, NL
17:40 – 18:10 KC 11	Thermal Transitions of Nonionic Detergent Micelles E. Grell ¹, H. Ruf ¹, M. Mutz ², M. von Raumer ³, A. Hörmann ³, R. Schneider ⁴, G. Ilgenfritz ⁴, I. Grillo ⁵, M. Kriechbaum ⁶, P. Laggner ⁶ 1 Max-Planck-Institut für Biophysik, Frankfurt a. M., D ² Novartis Pharma AG, Basel, CH ³ Solvias AG, Basel, CH ⁴ Institut für Physikalische Chemie der Universität Köln, D ⁵ Institut Max von Laue - Paul Langevin, Grenoble, F ⁶ Institut für Biophysik und Röntgenstrukturforschung, Österreichische Akademie der Wissenschaften, Graz, A
18:10 – 18:20	Break
	Chairman: U. Ch. Hofmeier
18:20 – 18:40 SC 19	Discrimination of Release Kinetics of Loaded Microbeads Designed for Embolisation: A New Methodology F. Amyot ¹, K. Jurski ¹, V. Boudy ², J.L. Counord ¹, G. Guiffant ¹, J. Dufaux ¹, J.C. Chaumeil ^{2 1} Laboratoire de Biorhéologie et d’hydrodynamique Physicochimique, C.N.R.S. 7057, Paris, F ² Service Recherche et Développement Galénique, Pharmacie Centrale des Hôpitaux de Paris
18:40 – 19:10 KC 12	Thermal Analysis for the Characterization of Drug Substances and Excipients E. Kaisersberger ¹, E. Marti ^{2 1} Netzsch-Gerätebau GmbH, Selb, D ² Solvias AG, Basel, CH
19:10	Closing of the PhandTA 5
19:45	Informal Dinner

Poster

PO A 1	Microcrystallisation – A Study of the Influence of the Substrate on Crystallisation and on the Formation of Polymorphic Forms O.M.R. Wenger ¹, A.G. Helg ², C. Marcolli ², M. Szelagiewizc ² ¹Pharmacenter of the University of Basel, Basel, CH ²Solvias AG, Basel, CH
PO A 2	Polymorphism of Oxybuprocaine-HCl A. Schmidt, U. Griesser, A. Burger University of Innsbruck, A
PO A 3	Thermal, Spectroscopic, X-ray Diffraction, and Microscopic Investigations of Glassy State of Doxazosin Mesylate M. Grcman ¹, F. Vrecer ², T. Meden ¹ ¹Krka d.d., Research and Development Division, Novo Mesto, Slo ²Faculty of Chemistry and Chemical Technology, University of Ljubljana, Slo
PO A 4	Application of DSC Method to Analyse Some Drugs g, b -Sterilized B. Marciniec¹, L. Wachowski² ¹Department of Pharmaceutical Chemistry, Karol Marcinkowski University Medical Sciences, Poznan, Poland ² Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland
PO A 5	Detection of Low Crystalline Amounts of a Drug Substance in Solid Dispersions by DSC K. Fiebich Novartis Pharma AG, Basel, CH
PO A 6	Synthesis and Applications of Some Polymeric Conjugates of Thymol or Eugenol A.G. Anghelescu-Dogaru ¹, G.C. Chitanu ¹, G.G. Bumbu ¹, A. Poiata ², C. Vasile ¹, A. Carpov ¹ ¹ Petru Poni Institute of Macromolecular Chemistry, Romanian Academy, Iasi, Ro ² Faculty of Pharmacy, Gr.T. Popa University of Medicine and Pharmacy , Iasi, Ro
PO A 7	Thermal Characterization of some New bis-Xanthine Derivatives G.G. Bumbu¹, L. Profire², Gh. Danila², C. Vasile¹ ¹ Petru Poni Institute of Macromolecular Chemistry, Romanian Academy, Iasi, Ro ² Faculty of Pharmacy, Gr.T. Popa University of Medicine and Pharmacy , Iasi, Ro
PO A 8	Thermomicroscopy and Differential Thermal Analysis of Terfenadine J. Canotilho ¹, S.R. Ferreira ², F.S. Costa ¹, A.T. Sousa ¹, J.S. Redinha ², M.L.P. Leitão ² ¹ Facultade de Farmacia, Universidade de Coimbra, P ² Faculdade de Ciências e Tecnologia, Universidade de Coimbra, P
PO A 9	Thermal Investigation of Propyphenazone-Caffeine Mixture B. Cetina-Cizmek¹, V. Grdinic¹, M. Tudja², P. Tudja², M. Horvat² ¹Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia ²PLIVA d.d., Zagreb, Croatia
PO A 10	The Characterisation of Pharmaceutical Powders by Solution Calorimetry F. Zaman, M. Mutz, P. Schwab, P. Piechon, D. Goldbronn, D. Giron Novartis Pharma AG, Basel, CH
PO A 11	Crystallization Development assisted by Lasentec FBRM P. Schirig PS Prozesstechnik GmbH, Basel, CH
PO A 12	On the Polymorphism of Plant Protection Substances: Physicochemical Properties of Metazachlor Crystal Forms D.K. Weigand, J.M. Rollinger, A. Burger University of Innsbruck, A
PO A 13	Studies on the Melting Process of Acetylsalicylic Acid Single Crystals G.L. Perlovich^1,2, A. Bauer-Brandl¹ ¹ Institutt for Farmasi, Universitetet i Tromso, Tromso, N ² Institute of Solution ChemistryRussian Academy of Sciences, Ivanovo, RUS
PO B 1	Control of Size and Morphology of a-Lactose Monohydrate Crystals by Using Structurally Related Additives. Possible Consequences by Dehydration Behaviour and Amorphization St. Garnier, S. Petit, G. Coquerel University of Rouen, Rouen, F
PO B 2	A Calorimetric Study of Phospholipid Hydration N. Markova¹, E. Sparr¹, L. Wadsö ², H. Wennerström¹ ¹Physical Chemistry, University of Lund, S ²Division of Building Materials, University of Lund, S
PO B 3	The Study of Vitamin C by Thermal Analysis and FTIR-Spectroscopy V. Wegmann, M. Egelkraut-Holtus, K. Pommerenke Shimadzu Deutschland GmbH, Duisburg, D
PO B 4	Study of Thermal Analysis of Di-Methacrylate of Tri-Ethylene Glycol J. Notay ¹, S.M. Dahiwale ¹, S.D. Pradhan ², S.S. Bhagade ³ ¹Naval College of Engineering, INS Shivaji Lonavla, India ²National Chemical Laboratory Pune, India ³Laxminarayan Institute of Technology, Nagpur University, Nagpur, India
PO B 5	Information about Morphology and Thermal Properties of Semisolid Phospholipid Preparations obtained by Electron Microscopy, DSC and Rheometry J. Bender and R, Schubert Department of Pharmaceutical Technology, University of Freiburg, D
PO C 1	The Effect of Punch Velocity on the Initial Compression Stage of Caffeine and Microcristalline Cellulose: Modelling by a Modified Heckel Equation C. Bürger, H. Leuenberger Pharmacenter, University of Basel, Basel, CH
PO C 2	Glassy Solid Solutions of Poorly Soluble Drugs in Isomalt for a Rapid Bioavailability M. Langer, N.A. Urbanetz, B.C. Lippold Institute of Pharmaceutical Technology, University of Düsseldorf, Düsseldorf, D
PO C 3	Stability Investigation of Drug-Cyclodextrin Inclusion Complexes M. Zelenak ¹, Z. Neizer ¹, Cs. Novak ¹, J. Sztatisz ¹, S. Gal ¹, G. Liptay ¹, V.J. Fernandes Jr. ², E. Carvalho ² ¹ Institute of General & Analytical Chemistry, University of Technics and Economics, Budapest, H ²Universidade Federal do Rio Grande do Norte, Natal, Brasil
PO C 4	Characterization of Thermal Stability by ADSC and TG-FTIR on Drugs F. Hoffmann Mettler-Toledo GmbH, Giessen, D
PO C 5	Studies on Biodegradable Silica fibers containing Dexmedetomidine T. Czuryszkiewicz¹, J. Ahvenlammi², M. Lindén¹ ¹ Department of Physical Chemistry, Abo Akademi University, Turku, FIN ² Institute of Fiber, Textile and Clothing Science, University of Technology, Tampere, FIN
PO D 1	Molecular Ionics of Anion Receptor Molecules: A Microcalorimetric Study D. Grell ¹, E. Grell ², P. Bugnon ³, B. Dietrich ¹, G. Quinkert ⁴, J.-M. Lehn ¹ ¹Institute Le Bel, Université Louis Pasteur, Strasbourg, F ² Max-Planck-Institut für Biophysik, Frankfurt a. M., D ³ Institute de Chimie Analytique, Université de Lausanne, CH ⁴ Institute for Organic Chemistry, J.W. von Goethe University, Frankfurt a. M., D
PO D 2	Effect of Chlorinated Phenols on the Structure of Model Membranes Á. Csizar¹, A. Bóta¹, Cs. Novak², G. Liptay², E. Klumpp ³, G. Subklew³ ¹ Institute of Phys. Chemistry, University of Technics and Economics, Budapest, H ² Department of General & Analytical Chemistry, Univ. Techn. Econ., Budapest, H ³ Institute of Applied Physical Chemistry, Research Centre Jülich, D
PO E 1	Temperature Dependence of the Raman Spectra of Amorphous Glucose S. Söderholm, N. Meiander, Y.H. Roos University of Helsinki, FIN
PO E 2	Applications of TGA-MS-Coupling R. Schiller Schering AG, Berlin, D
PO E 3	Progress in the Standardisation of Particle and Surface Characterisation E. Robens ¹, K.-F. Krebs ², K. Meyer ³, K.K.Unger ¹, A.Dabrowski ⁴ ¹Institute of Anorg. and Analytical Chemistry, J. Gutenberg University, Mainz, D ²Merck KGaA, LAB CHROM Synthese, Darmstadt, D ³Bundesanstalt für Materialforschung und -prüfung, Berlin, D ⁴Faculty of Chemistry, Maria Curie-Sklodowska University, Lublin, Poland
PO E 4	Application of Jäntti's Method for General Use J.A. Poulis¹, C.H. Massen¹, E. Robens², P. Staszczuk³ ¹Faculty of Technical Physics, Technical University Eindhoven, NL ²Institute of Anorg. and Analytical Chemistry, J. Gutenberg University, Mainz, D ³Faculty of Chemistry, Maria Curie-Sklodowska University, Lublin, Poland
PO E 5	Coupled DSC-Microscope System and its Application to Pharmaceuticals K. Pommerenke, M. Ohta Shimadzu Deutschland GmbH, Duisburg, D
PO E 6	40 Jahre Shimadzu Thermoanalyse K. Holtzhauer Shimadzu Schweiz GmbH, Reinach, CH
PO E 7	Indirect Calorimetry of Human Body Surface and New Force in Human Space-Time A. Shiraishi Shiraishi Hospital, Kosei-cho, Okayama City, J
PO E 8	Thermodynamic Study of Electrolytes Solutions. Thermodynamic Properties of Ammonium Aqueous Electrolytes Solutions from Solubility Measurement R. Sirbu Faculty of Pharmacy, "Ovidius" University, Constanza, Ro
PO E 9	Thermodynamic Properties of NaSCN and KSCN in Binary and Ternary Aqueous Solutions at Liquid-Solid Equlibrium R. Sirbu ¹, M. Sirbu ² ¹Faculty of Pharmacy, "Ovidius" University, Constanza, Ro ²Mircea cel Batrân, College of Constanza, Ro
PO E 10	The Ionic Activity Coefficients of Electrolytes in Aqueous Solutions Using Selective Electrodes and Cryoscopic Data R. Sirbu ¹, M. Sirbu ² ¹Faculty of Pharmacy, "Ovidius" University, Constanza, Ro ²Mircea cel Batrân, College of Constanza, Ro
PO E 11	Scanning Microcalorimetry Investigation of Native and Iodized Spirulina Platensis Cell Culture L. Topehishvili, G. Majagaladze, D. Tananashvili, J. Monaselidze Institute of Physics, Georgian Academy of Sciences, Tbilisi, Georgia
PO E 12	DSC by TGA/SDTA 851^e Considering Mass Changes R. Riesen, K. Vogel Mettler-Toledo GmbH, Schwerzenbach, CH
PO E 13	Expansion and Modulus Measurements during Shrinkage of Fibers; Simultaneous Load- and Temperature-Modulated TMA R. Riesen, J.K.E. Schawe Mettler-Toledo GmbH, Schwerzenbach, CH