PhandTA 6




The final timetable of the scientific program will become available beginning of May 2002. Below you may find a tentative timetable of the event and the  list of contributions. To see abstracts already available please click on the according pdf icon.

The Scientific Program will be presented as
Award Lectures (AL, 50 min)
Plenary Lectures (PL, 50 min)
Key Communications (KC, 30 min)
Short Communications (SC, 20 min)
Workshop on Thursday, see below


Monday, May 27 through Wednesday, May 29, 2002

Sunday, May 26, 2002
14:00 General Assembly of the European Society 
for Applied Physical Chemistry
15:00 Registration for the Conference and for Accomodation
16:30 Opening of the PhandTA 6 


09:00 - 18:00 Award Lectures, Main Lectures, 
Key and Short Communications, 
Poster Sessions, Exhibition of Instruments

Thursday, May 30, 2002

Special Workshop with the Subject:
"The Variety of Drug Substances in the Solid State 
and Production Pathways for their Making"
Theoretical and Experimental Aspects


Award Lectures 

Characterization of Drug Substances by Physicochemical Methods
E. Marti
c/o Novartis Pharma AG, Basel, CH

Plenary Lectures 

Biophysical Analytics of Single Molecules
D. Anselmetti
Universität Bielefeld, D

Physico-Chemical Aspects of Polymorph Prediction
H.-B. Bürgi
University of Bern, CH
NMR Spectroscopy of Biomolecular Interactions
St. Grzesiek, F. Cordier, A. Dingley, J. Kahman, M. Allan, D. Häussinger, H.-J. Sass, V. Jarvine
Biocenter of the University of Basel, CH

Freeze Drying of Pharmaceuticals: A Review of Critical Parameters
M.J. Pikal
University of Connecticut, USA

The Lipid Bilayer: Specific and Non-specific Interactions with Surfactants, Peptides, and Proteins
J. Seelig
Biocenter of the University of Basel, CH

Particle Design for Drug Delivery Systems
P. York
University of Bradford, UK

Key Communications 

Flow Microcalorimetry: Theory, Test Reactions and Applications
A.E. Beezer, M.A.A. O’Neill, J.A. Connor, J.C. Mitchell, J. Orchard
University of Greenwich at Medway, Kent, UK


Intermolecular Interactions in Solid Drugs – What can High-Pressure Techniques Contribute to their Study ?
E. Boldyreva
Russian Academy of Sciences, Rus


Characterization of Salts of Drug Substances
D. Giron
Novartis Pharma AG, Basel, CH


Nucleotide / Protein Interaction: Energetic and Structural Features
E. Grell, E. Lewitzki, A. Schacht
Max-Planck-Institut für Biophysik, Frankfurt / M., D


Moisture Sorption Studies in the Characterization of Drug Hydrates
U.J. Griesser
Universität Innsbruck, A


The Combination of UV/VIS/IR Spectroscopy with Isothermal Fluxmetry and Isoperibolic Calorimetry to Perform and Monitor Polymerization in Organic Media
F. Dan, J.-P.E. Grolier
Université Blaise-Pascal, Aubiere, F


High Throughput Polymorphism Screening: Just the first Step for Integrated Crystal Engineering
R. Hilfiker, U.Ch. Hofmeier, C. Marcolli, M. Szelagiewicz J. Berghausen
Solvias AG, Basel, CH


Relation of Drug Substances to Solvents: Free Solvent, Adsorption, Inclusion and Intercalation
E. Kaisersberger1 and E. Marti2
1Netzsch Gerätebau GmbH, Selb, D
2c/o Solvias AG, Basel, CH


Simultaneous Coupling of DSC and Time-Resolved Synchroton X-ray Diffraction for the Study of Colloids of Pharmaceutical Interest
M. Ollivon, S. Lesieur, C. Grabielle-Madelmont, C. Lopez, G. Keller, K. Andrieux, D. Kalnin
Université Paris Sud, Châtenay-Malabry, F

Mechanical and Physico-Chemical Characterization of Excipients in Order to Define their Applicability for Tabletting
K.M. Picker
Martin Luther University, Halle, D

Oscillating Crystallisation of a Chiral Compounds in Quasi-racemic Solution; Evidence of a Multiepitaxy Crystal Growth Mechanism and Influence of Stirring
C. Gervais, St. Beilles, S. Petit, G. Coquerel
Université de Rouen, Mont Saint Aignan, F


Polymorphism Investigations and Structure Elucidation of Pharmaceuticals in Development
S. Pfeffer-Hennig, E. Tedesco, P. Piechon, M. Bellus, C. Goldbronn
Novartis Pharma AG, Basel, CH

KC Crystallization in Capillary Spaces: Preparation and Characterization of a Novel, High-Energy Polymorph of Nabumetone
L.J. Chyall, J.M. Tower, D.A. Coates, T.L. Houston, G.P. Staehly
SSCI, Inc., West Lafayette, IN, USA

Industrial Crystallization: Some Fields of Problems - Polymorphs, Pseudopolymorphs and Impurities
J. Ulrich and C. Strege
Martin-Luther-Universität Halle-Wittenberg, D


Anti-Thermodynamic Transitions of Sulphathiazole Polymorphs
T.L. Threlfall 1 and Bob Lancaster 2
1University of York, UK
Glaxo SmithKline, Stevenage, UK


Microemulsions as Reactors for Nanoscopic Materials
A. Weidenkaff and A. Reller
Universität Augsburg, D


Hydrophobic Interactions: Selected Results on Simple Model Systems
E. Wilhelm
Universität Wien, A

Short Communications 

The use of solution calorimetry in assessing partially amorphous dry powder inhalation carriers
D. Al-Hadithi 1, G. Buckton 1, S. Brocchini 1, N. Lowther 2, D. Singh 2
1 School of Pharmacy, London, UK, 2 Novartis Pharma AG, Basel, CH


Solid State Chemistry & Pharmacy
V. Boldyrev
Novosibirsk State University, Rus

Non Thermally Driven Transformation of Molecular Compounds
M. Descamps, J.-F. Willart, A. de Gusseme, S. Desprez
Université de Lille, Villeneuve d'Ascq, F


The Use of Organic Vapour Atmospheres to Quantify Amorphous Content in Pharmaceutical Substances by Isothermal Microcalorimetry
S. Garnier, M. Mutz, D. Giron
Novartis Pharma AG, Basel, CH


Very High Sensitivity DSC and Titration Calorimetry Applied to the Study of Proteins
M. Giordano, R. Naumann, L. Benoist
Setaram, Caluire, F

Cyclodextrin Chemistry: Review of Results by Thermal Analysis
B. Glass1, M. Brown2, F. Giordano3, J.R. Moyano3, Cs. Novak4
1 James Cook University, Townsville, Australia
2 Rhodes University, Grahamstown, Sout Africa
3 University of Parma, I
4 Budapest University of Technology and Economics, H


Calorimetric Determination of Thermodynamics and Kinetics of Water Vapor Sorption
F. P. Hoffmann
Mettler-Toledo GmbH, Gießen, D

An Example of Polymorphism in Pharmaceutical Development
P. Johansson
Thermometric AB, Järfälla, S

Solubility of Nonelectrolytes in Water: A Thermodynamic and Quantum Chemical Approach based on Dihydroxynaphthalene Derivatives 
Ch. Machon, I. Zimmermann
University of Wuerzburg, Institute of Pharmacy and Food Chemistry, Wuerzburg, D

Physical Characterization of Pharmaceutical Hydrates
M. Mutz
Novartis Pharma AG, Basel, CH

SC Thermoanalytical Investigation of Supramolecular Compounds
G. Pokol, Cs. Novak, R. Illes, Cs. Kassai, D. Kozma, E. Fogassy
Budapest University of Technology and Economics, H

Development- and Quality-Control for Molecules of Pharmaceutical Interest by MID-IR and NIR Techniques
A. Rager, M. Boese and H. Weiler
Bruker Optik GmbH, Ettlingen, D

Adventures and Surprises in X-Ray Diffraction Experiments and Crystal Structures Analyses. Selected Examples
H.W. Schmalle
Institute of Inorganic Chemistry, University of Zurich, CH

Measuring Surface Energy, Surface Heterogeneity, and Vapor Permeability of Pharmaceutical Powders using Chromatographic, Microbalance, and Microcalorimetric Methods
T. D. Sokoloski1, F. Thielmann2, J. Opfermann3, D. Burnett2, M. Barnett1, R. Mueller1, M. B. James1
1 GlaxoSmithKline WW Physical Properties, 
2 Surface Measurement Systems Ltd., London, UK, 
3 Netzsch Gerätebau GmbH, Selb, D

New Advances in the Application of Inverse Gas Chromatography (IGC) for the Physical Characterisation of Pharmaceuticals
F. Thielmann, D. Williams, C. Levoguer, S. Reutenauer
Surface Measurement Systems Ltd., London, UK

PO Infrared Spectroscopy in the Study of Terfenadine Phase Transitions
J. Canotilho2, M. E. Eusébio1, F.S. Costa2, A.T. de Sousa2, J.S. Redinha1, M. L.P. Leitão1
Faculdade de Ciências e Tecnologia, Universidade de Coimbra, P
2Faculdade de Farmácia, Universidade de Coimbra, P
Synthesis and Calorimetric Investigation of Unstable b-Glycine
V.A. Drebushchak1,2, E.V. Boldyreva2,3, T.N. Drebushchak2,3, E.S. Shutova2
Institute of Mineralogy and Petrography, Russian Academy of Sciences, Novosibirsk, Rus
2 Novosibirsk State University, Rus
3 Institute of Solid State Chemistry & Mechanochemistry Russian Academy of Sciences, Novosibirsk, Rus
PO Investigation of Water Diffusion into the Silicone Elastomers
J. Fodor, Ö. Wagner, P. Hencsei, J. Nagy, G. Liptay
Budapest University of Technology and Economics, H
PO Tetramorphism of Fananserine: when a well defined strategy coupling state-of-the-art approaches in crystallography and thermodynamics also allows to elucidate complex polymorphism cases
J. Giovannini1,2, S. Toscani3, R. Céolin3, L. Ter Minassian3, M.-A. Perrin1, A. Rameau1, D. Louër2, F. Leveiller1,4 
1 Aventis Pharma, Vitry sur Seine, F
2 Rennes University, F
3 Paris V University, Paris, F
4 AstraZeneca R&D, Lund, S
PO "Polymorphism" and Hydration of Zopiclone : How to Give the Marketed Drug a Real Identity Card !
J. Giovannini1,2,, P. Espeau3, S. Toscani3, R. Céolin3, M.-A. Perrin1, A. Rameau1, D. Louër2, F. Leveiller1,4
Aventis Pharma, Vitry sur Seine, F
Rennes University, Rennes, F
Paris V University, F
4 AstraZeneca R&D, Lund, S

Efficient use of TG-MS Coupled Technique in Pharmaceutical Development
D. Giron, P. Piechon, S. Pfeffer
Novartis Pharma AG, Basel, CH


Supramolecular Structures with Peroxides as possible Active Long-Lived Drug Substances
E.G. Ippolitov, T.A. Tripolskaya, G.P. Pilipenko, I.V. Pokhabova
Kurnakov Institute, Moscow, Rus


Formation of New Crystalline Phases by means of Solvent Exchange and Growth of Whisker-like Crystals
F. Mallet, S. Petit, S. Laffont, P. Billot, G. Coquerel
Université de Rouen, Mont Saint Aignan, F

Application of Supercritical Carbondioxide in the b-Cyclodextrin Inclusion Complexes 
Marongiu, A. Piras, S. Porcedda
Universita di Cagliari, I

Thermal Characteristics of Macroalgae Spirulina Platensis Cells at Various Values of pH Medium in Temperature Range 5-140°C. DSC Investigation
J. Monaselidze, Sh. Barbakadze, T. Kvirikashvili, L. Topchishvili
Georgian Academy of Sciences, Tbilisi, Republic of Georgia


Microcalorimetric Investigation of Hydrated Water of Rat Skin Collagen in the Temperature Range 20-106°C
J.Monaselidze1, I.Mesropyan1, G.Majagaladze1, Sh.Barbakadze1, Th.Burjanadze2
Institute of Physics, Georgian Academy of Sciences
2 A.Natashvili Institute of Experimental Morphology, Georgian Academy of Sciences

PO Development of Nitric Oxide Releasing Silicone Polymers
A. Osvald, Ö. Wagner, P. Hencsei, J. Nagy, G. Liptay
Budapest University of Technology and Economics, H

Thermal Investigations of Morphine and its Derivates in Biological Samples
Cs. Novak1, O. Bene1, Zs. Ehen1, G. Pokol1, F. Giordano2, S. Hosztafi3, J. Sztatisz1, S. Gal1
1 Institute of General and Analytical Chemistry, Budapest University of Technology and Economics H
2 University of Parma, Department of Pharmacy, I
3 ICN Hungary Ltd., Tiszavasvari, H


Application of Raman and IR Spectroscopy in Pharmaceutical Development
S. Pfeffer-Hennig and M. Bellus
Novartis Pharma AG, Basel, CH


The Study of Ibuprofen by DSC and TGA
K. Pommerenke
Rheometric Scientific GmbH, Munich, D


Lyophilization Optimization Using DSC and MT-DSC
A. Rameau and C. Neves
Aventis Pharma, Vitry sur seine, F

Thermoanalytical Investigation of the Complex Binary System of (+)- and (-)-diprophylline
J.M. Rollinger 1, U.J. Griesser 1, M. Szelagiewicz 2, U. Hofmeier 2
1 University of Innsbruck, A
2 Solvias AG, Basel, CH
Crystal Polymorphism of Pramocaine and Pramocaine Hydrochloride
A.C. Schmidt, N. Senfter, U.J. Griesser
University of Innsbruck, A
PO Solid-State Form Analysis in Drug Product by FT-Raman Spectroscopy
R.L. Te, P.A. Martoglio-Smith, D.E. Bugay, Ch.J. Rojewski1
SSCI, Inc., West Lafayette, IN, USA
1TAP Pharmaceutical Products Inc., Lake Forest, IL, USA
PO A Computer Simulation Based Screening Method for Crystallization Processes
V. Thome, H. Pontius, P.B. Kempa, M. Dörich, M. Herrmann
Fraunhofer Institut für Chemische Technologie, Pfinztal, D
PO tbd
G. Wang
China Pharmaceutical University, Tong Jia Xiang, China
PO tbd
Z. Zhang
China Pharmaceutical University, Tong Jia Xiang, China


  © eurostar-science  2002;  last changes: May 01, 2002 by katiniko