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PhandTA 4

     4th Symposium/ Workshop on Pharmacy and Thermal Analysis
Tulla-Hörsaal, University of Karlsruhe, Germany
March 23-26, 1999

     is over.

See you at PhandTA 5 September 2000 in Basel, Switzerland.

Information about PhandTA 4

Organizing Committee

Scientific Program



Organizing Committee

Dr.E. Marti*, President, c/o Novartis Services AG, Basel, CH
Prof. Dr. H. Leuenberger, Institute of Pharmacy, University of Basel, CH
Prof. Dr. E. Doelker, Laboratoire de Pharmacie Galénique, University of Genève, CH
Prof. Dr. H.E. Junginger, Center for Drug Research, University of Leiden, NL
Prof. Dr. V. Krämer*, Institute of Crystallography, University of Freiburg, D
Mr. N. Martin, Secretary, Novartis Services AG, Basel, CH
Prof. Dr. K.H. Bauer, Institute for Pharmaceutical Technology, University of Freiburg, D
Prof. Dr. A. Beezer*, Chemical Laboratory, University of Kent, Canterbury, UK
Prof. Dr. J. Bernstein, Ben-Gurion University, Beer-Sheva, Israel
Prof. Dr. A. Burger, Institute of Pharmacognosy, University of Innsbruck, A
Prof. Dr. St. R. Bryn, Dep. of Industry and Physical Pharmacy, Purdue University, West Lafayette, USA
Mrs. Prof. Dr. M.T. Clavaguera-Mora, Departement de Fisica, University Autònoma de Barcelona, E
Dr. W.-D. Emmerich*, Netzsch-Gerätebau GmbH, Selb, D
Mrs. Dr. D. Giron*, Novartis Pharma AG, Basel, CH
Dr. E. Grell, Max Planck Institute of Biophysics, Frankfurt a. M., D
Prof. Dr. J.-P.E. Grolier, Université Blaise Pascal, Aubière, F
Mrs. Prof. Dr. A.M. Guyot-Hermann, Faculté de Pharmacie, Université de Lille, F
Dr. U.Ch. Hofmeier, Novartis Services AG, Basel, CH
Mrs. Prof. Dr.-Ing. E. Ivers-Tiffée, University of Karlsruhe, D
Prof. Dr. H.R. Oswald*, Institute of Inorganic Chemistry, University of Zürich, CH
Prof. Dr. Y.H. Roos, Department of Food Technology, University of Helsinki, SF
Prof. Dr. I. Wadsö, University of Lund, S
Prof. Dr. E. Wilhelm*, Department of Physical Chemistry, University of Vienna, A
Prof. Dr. E. Windhab, Inst. of Food Science/ Food Engineering, Swiss Fed. Inst. of Technol. Zürich, CH

* Members of the Board of eurostar

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M. Holz; University of Karlsruhe, D
"Recent Nuclear Magnetic Resonance (NMR) Studies of Water Dynamics near Nonpolar Solutes and of Hydrophobic Association Phenomena"

M. Ollivon, C. Lopez, K. Andrieux; URA1218 CNRS, Chatenay, F
C. Bourgaux, P. Lesieur; LURE, Orsay, F
"Study of Lipidic Structures and their Phase Transitions using Coupled Time-Resolved SAXS and WAXS with DSC Technique"

Mrs. M.T. Clavaguera-Mora1, A. Gracia2, C. Comas1, N. Clavaguera3, J. Fontán1
1 Universitat Autònoma de Barcelona, E;
2 FARMHISPANIA, Montmeló, E ; 3 Universitat de Barcelona, E
"A new Technique for the Measurement of the Melting Point: Application to Drug Substances"

A. Rager1, E. Treser2
1 Bruker Optik GmbH, Karlsruhe, D; 2Netzsch-Gerätebau GmbH, Selb, D
"TG - FTIR: one System, twice the Power!"

E. zur Mühlen1, A. Lippacher2, W. Mehnert2, R.H. Müller2
1TA Instruments GmbH, Alzenau, D; 2 University of Berlin, D
"Application of micro Thermal Analysis (mTAÔ) to the Study of Solid Lipid Nanoparticles"

Workshop 1: J.-P.E. Grolier, E. Marti
"Instrumentation and Methods"

D.R. Williams, D. Butler; Surface Measurement Systems, London, UK
"Inverse Gas Chromatography of Particulate Materials:  Surface Energetics and Morphology"

Mrs. N. Markova, L. Wadsö; University of Lund, S
"A Microcalorimetric Technique to Study Vapor Sorption"

JL. Daudon, L.Benoist, G. Hurel, C. Mathonat, R. Neumann, P. le Parlouer
SETARAM, Caluire, F
"SETline: Rapid Quality Control of Materials using Thermal Analysis based on an Integrated Circuit Detector"

Mrs. H. Lopez de Diego; H. Lundbeck A/S, Valby, DK
"Unexpected Precipitation in Aqueous Solution, an Example of Combined Solvate Formation and Polymorphism"

M. Boese; Bruker Optik GmbH, Karlsruhe, D
"New IR Spectroscopic Method for the Characterization of Drug-Target Interactions"

A. Hörmann; Novartis Services AG, Basel, CH
"Thermodynamics of Nucleic Acid Hybridization: A Comparison of Different Approaches"

C. Habare, S. Petit, G. Coquerel; Université de Rouen, F
"Desolvation of Solvates: Possible Application for the Research of New Polymorphic Forms"

J.-O. Henck1, J. Bernstein2
1University of Innsbruck, A; 2Ben-Gurion University, Beer Sheva, Israel
"Disappearing and Reappearing Polymorphs"

J.D. Dunitz; Swiss Federal Institut of Technology, ETH Zürich, CH
"Virtual Crystallography: Are Crystal Structures Predictable?"

Mrs. C. Marcolli, M. Szelagiewicz; Novartis Services AG, Basel, CH
"Hot-Stage Raman Microscopy: a New Tool for the Investigation of Polymorphic Forms"

S.R. Byrn1, X. He1, U. Griesser2
1Purdue University, West Lafayette, Indiana, USA, 2University of Innsbruck, A
"Crystallization Control Using Energy-Temperature Diagrams"

Workshop 2: S.R. Byrn, E. Marti, H.R. Oswald
"Crystallization and Characterization of Drug Substances"

S. Walter , A.H. Mebarek, S. Helle; University of Mulhouse, F
"Dangerous Behaviour of Metal-Organic Reactions induced by Interface Charge Build-Up"

Mrs. M. Ribeiro, J.-P.E. Grolier; Université Blaise Pascal, Aubière, F
"Applications of Temperature Modulated DSC. Optimization of Experimental Parameters and Recent Studies"

O. Bustin, M. Descamps; Université de Lille, Villeneuve, F
"Specific Heat Spectroscopy Measurements by MDSC: Characterization of the Fragility of Pharmaceutical Glass Formers"

H. Möhler; Polytechnic of Würzburg, D
"Thermal Analysis and Conventional Testing Methods of Plastics and Rubber"

Mrs. D. Giron, C. Goldbronn, P. Piechon, S. Pfeffer-Hennig
Novartis Pharma AG, Basel, CH
"Polymeric Excipients in Drug Products"

V. Samouillan1, A. Lamure1, J. Dandurand1, E. Maurel1, C. Lacabanne1,
W. Hornebeck2
1Université Paul Sabatier, Toulouse, F; 2 Faculté de Medicine, Reims, F
"Evolution of Molecular Mobility of Elastin upon Enzymatic Degradation"

STK Award Young Scientists for "Solid State Characterization in Pharmacy"
presented to U.J. Griesser

U.J. Griesser1, M. Szelagiewicz2, U.Ch. Hofmeier2, S.R. Byrn3, A. Burger1
1 University of Innsbruck, A; 2 Novartis Services AG, Basel, CH
3 Purdue University, West Lafayette, Indiana, USA
"Old and New Aspects of the Polymorphism of Caffeine and Theophylline and its Implications in Drug Formulation"

M. Epple1, A. Reller2
1University of Hamburg, D; 2University of Augsburg, D
"Biomineralization for Biomedical Application ?"

V.V. Boldyrev, Mrs. T.P. Shakhtshneider
Russian Academy of Sciences, Novosibirsk, Russia
"Modifying Properties of Drugs by Mechanical Treatment "

B.G. Sarraf, H. Tissot, P. Tissot, D. Alfonso, R. Gurny, E. Doelker
University of Geneva, CH
"Differential Scanning Calorimetry Study of the Influence of Hot-Melt Extrusion and Compression Molding on Polymer Structure Arrangement"

E. Wilhelm; University of Vienna, A
"Unusual Thermophysical Behavior of Liquids, Pure and Mixed"

E. Kaisersberger1, E. Treser1, E. Marti2, A. Geoffroy2
1Netzsch-Gerätebau GmbH, Selb, D; 2Novartis Services AG, Basel, CH
"Thermal Characterization of Natural Drug Substances by Traditional Thermoanalytical Methods and by TG-FTIR"

H.-G. Wiedemann; Mettler-Toledo GmbH, Schwerzenbach, CH
"Distinction of Original and Forged Lithographs by Means of Thermogravimetric Investigation of the used Paper"

R.B. Peters; ALV-Laser VertriebsGmbH, Langen, D
"High Sensitivity and High Concentration Range Particle Sizing Unit, ALV – NIBS / HPPS using Laser-Light Backscattering"

Mrs. N.A. Urbanetz, B.C. Lippold; University of Düsseldorf, D
"Effect of Humidity on the Physical Stability of Solid Dispersions of Nimodipine and Polyoxyethylene - DSC and Hot Stage Microscopy Investigations"

V. Samouillan1, A. Lamure1, J. Dandurand1, E. Maurel1,
C. Lacabanne1, M. Spina2
1 Université Paul Sabatier, Toulouse, F; 2 Universita di Padova, I
"Structural Modifications Associated with Non Specific Abdominal Aortic Aneurysms in Human Aortic Wall"

H.R. Oswald; University of Zürich, CH
"Topochemistry and Solid State Characterization of Drugs"

Mrs. S. Pfeffer-Hennig, S. Petit, L. Viola, P. Piechon,
D. Giron, C. Goldbronn
Novartis Pharma AG, Basel, CH
"Crystal Engineering: A Step Towards the Understanding and Rational Investigations of Polymorphism and Drug Substance Properties"

B.D. Glass, M.E. Brown, M. Lebete, D.V. Eve,
Rhodes University, Grahamstown, South Africa
"Thermal Analysis Studies on Structurally Related Phenothiazines with Selected Cyclodextrines in Order to Correlate Inclusion Complexation with Photostability"

Y.H. Roos; University of Helsinki, Finland
"Water Interactions in Concentrated Carbohydrate Structures"

K.H. Bauer, T. Reinhart, G. Eisenmann, R. Stenz
University of Freiburg i.Br., D
"Polymeric Surfactants with Low Hemolytic Activity"

Workshop 3: Mrs. D. Giron, Y.H. Roos
"Dosage Forms: Is a Rational Development Possible"

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Poster Presentation

"Polymorphism of L-Citrulline"

H.Allouchi, V.Agafonov; University of Tours, F
A. Dzyabchenko; Karpow Institute of Physical Chemistry, Moscow, RU
J.Ll. Tamarit; Universitat Politecnica de Catalunya, Barcelona, E
R.Céolin, S.Toscani; Université Paris V, F
F.Lepage; Laboratoires BIOCODEX, Compiègne, F
"Thermodynamic Stability and FTIR Microscopy of 8-Hydroxyquinolin Polymorphs"

M.E. Auer, U.J. Griesser, A. Burger; Universität Innsbruck, A
"Generation and Characterisation of a new Polymorph of a Chroman Derivative using Differential Scanning Calorimetry and Variable Temperature Infrared Microspectrometry"

D.J. Busby, D.C. Lee, M.J. Raw; SmithKline Beecham Pharmaceuticals, Harlow, UK
"DSC Study of Binary Systems of Naproxen with Amorphous and Crystalline Methyl-b -Cyclodextrin"

G.P.Bettinetti, A.Negri, M.Sorrenti; University of Pavia, I
P.Mura, M.T.Faucci; University of Firenze, I
"Thermal Behaviour, Physical Stability and Dissolution Properties of Picotamide Monohydrate and Anhydrate"

G.P.Bettinetti, M.Sorrenti, A.Negri; University of Pavia, I
P.Mura, M.T.Faucci;, University of Firenze, I
"Research Proposal for for Paracetamol: Are Electric Fields a decisive Factor for the Crystal Growth of a Specific Polymorph?"

S. Cianferani1, M.Szelagiewicz2, S.Walter1, E. Marti2;
1University of Mulhouse, F
2Novartis Services AG, Basel, CH
"Three Phases Model for Semicrystalline Excipients"

J.Dandurand, A.Lamure, E.Maurel, M.J.Fauran, C.Lacabanne
Université Paul Sabatier, Toulouse, F
"Microcalorimetry, a Promising Tool for Identifying the Stability of Pharmaceuticals"

W.P.C. de Klerk; TNO Prins Maurits Laboratory, Ryswyk, NL
"Characterization of Hydrates. Case Study"

S.Pfeffer-Hennig, D.Giron, C.Goldbronn, P.Piechon, M.Bellus; Novartis Pharma AG, Basel, CH
"Determination of Amorphous Content in Drug Substances: Comparison of Several Methods"

D.Giron, C.Goldbronn, M.Mutz, S.Pfeffer-Hennig, P.Piechon; Novartis Pharma AG, Basel, CH
"Automation in Thermogravimetry: Application for Pharmaceuticals"

D.Giron, C.Goldbronn, S.Pfeffer-Hennig; Novartis Pharma AG, Basel, CH
"Polymorphism and Chiral Components"

C.Habare, S.Petit, G.Coquerel; University of Rouen, F
"On-line monitoring of polymorphic changes in processes by spectroscopic techniques"

A.Helg; I.D. Macklam; Novartis Services AG, Basel, CH
B.C. Stahl; Novartis Animal health AG, Basel, CH
"Energy/Temperature-Diagram and Solid-State NMR Spectra of Polymorphous Tedisamil Dihydrochloride"

J.-O.Henck; A.Burger, University of Innsbruck, A
E.Finner, H.Vogel-Lahrmann; Solvay Pharmaceuticals GmbH, Hannover, D
"Thermal Analysis performed by X-Ray Diffraction"

M. Herrmann, W. Engel, S. Haaga
Fraunhoferinstitut für Chemische Technologie, Pfinztal-Berghausen, D
"PulseTAâ : Quantification of FTIR Signals "

M.Maciejewski1, F.Eigenmann1, A. Baiker1, W.-D.Emmerich2, E.Treser2
1 Swiss Federal Institute of Technology, Zürich, CH
2 Netzsch Gerätebau GmbH, Selb, D
"Thermoanalytical Investigations of Crystalline and Amorphous Forms of a Drug Candidate"

Steffen Neuenfeld; Merck KG aA, Darmstadt, D
"Preparation and Solid Phase Properties of Anti-Inflammatory Drug – Cyclodextrin Complexes"

Cs. Novak1, V.J.Fernandez2, E.A. Carvalho2, G. Pokol1, G.P. Bettinetti3, F. Giordano4, S.Gál1,
G. Liptay1
1Technical University of Budapest, H; 2University of Natal, Brazil
3University of Pavia, I; 4University of Parma, I
"The Formation Enthalpies of Cyclic Phosphinesulphides in Condensed and Gaseous Phases"

V.V.Ovchinnikov, L.I.Lapteva; Kazan State Academy of Construction,Ru
E.Yu.Sitnikova; Academy of Sciences of Russia, Kazan, Ru
"Thermochemistry of Cyclic Tertiary Phosphines with the Useful Biological Properties"

V.V.Ovchinnikov, L.R.Khazieva, L.I.Lapteva, E.E.Shishova
Kazan State Academy of Construction and Architecture, Ru
"The Thermal Behaviour of OCABEF-Ligand and [Cu(OCABEF)2] Complex"

V.Popescu, I.Carazeanu, A.Dumbrava; University of Constantza, Ro
"Copper-Chlorophyll-Antitumoral Agent"

V.Popescu, R.Sirbu, I.Carazeanu; University of Constantza, Ro
"Hydrates Solid-State Characterization: General Methodology and a Case Study"

A.Rameau, A.-L. Guilloux, F. Leveiller; Rhone Poulenc Rorer, Vitry, F
"DSC Characterization of the Superelasticity of Orthodontic NiTi-Springs"

J.M.Rollinger, O.Barwart*, A.Burger; University of Innsbruck, A; *Färbergasse 15, Dornbirn, A
"Calibration Method of Human Body Surface Energy on Superficial Thermal Gradient"

A. Shiraishi; Shiraishi Hospital, Okayama-City, J
"On the Polymorphism of Plant Protection Substances: Thermal Analysis of the Binary System of Triadimenol"

Ch.van den Boom, J.-O.Henck, A.Burger; University of Innsbruck, A
"Investigation of Drug-Polymer Interaction in the Silicone Elastomers"

Ö.Wagner, P.Hencsei, G.Liptay; Technical University of Budapest, H
G.Kenessey; MOL Hungarian Oil and Gas Co., H
"On the Polymorphism of Plant Protection Substances: Four Modifications of Triadimefon"

D.K.Weigand, J.-O. Henck, A.Burger; University of Innsbruck, A

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The following Instrument Manufacturers
exhibited their Products at the PhandTA 4:

Karlsruhe, Germany
Baldham, Germany
Bletchley, Milton Keynes, United Kingdom
Tadworth, Waterfield, United Kingdom
Giessen, Germany
Selb, Germany
Langen, Germany
Frankfurt, Germany
Caluire, France
Duisburg, Germany

Alzenau, Germany

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